The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step

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Authors: Piia Kokkonen, Michaela Slanska, Veronika Dockalova, Gaspar P. Pinto, Esther M. Sánchez-Carnerero, Jiri Damborsky, Petr Klán, Zbynek Prokop, David Bednar

Journal title: Computational and Structural Biotechnology Journal

Journal number: 18

Journal publisher: Elsevier

Published year: 2020

Published pages: 805-813

DOI identifier: 10.1016/j.csbj.2020.03.017

ISSN: 2001-0370