Periodic Reporting for period 1 - Tex-Mex (A synthetic biology approach to engineering exhaustion-free T cell therapies. Uncovering and counteracting biomechanical triggers of T cell dysfunction in the tumour microenvironment.)

Cancer is the second leading cause of death in the EU, accounting for 1.4 million deaths and 3 million new cases in 2018, with an estimated healthcare cost of €130 billion each year. Cancer is also one of the five priority mission areas of Horizon Europe 2021-2027. Chimeric...