Necessary approvals and permits obtained and submitted to the Commission

For HUMAN EMBRYOS/FOETUSES (after GA) : 1. All the Human Pluripotent Stem Cells lines to be used must be registered in hPSCreg, copy of registration must be provided to REA 2. Human Neural Stem Cell lines lines to be used must be registered in hPSCreg ; copy of registration must be provided to REA 3. The project must be registered in hPSCreg and copy of this registration must be provided to REA For HUMAN CELLS / TISSUE (after GA, before the commencement of the research work) : 1. Copies of ethical/regulatory approvals must be submitted prior to the start of the relevant research activities. For ANIMALS (after GA, before the commencement of the research work): 1. Copies of ethical / regulatory approvals for the work to be carried out with animals must be submitted prior to the start of the relevant research activities. 2. Copies of personal licences and training certificates for the work to be carried out with animals (as indicated in the Part B Ethics Section) must be submitted prior to the start of the relevant research activities. If licences or training certificates expire during the course of the research, renewed documentation must be submitted in due time. For THIRD COUNTRIES (throughout the project): 1. The applicant must confirm that the ethical standards and guidelines of Horizon2020 will be rigorously applied, regardless of the country in which the research is carried out 2. The ethics advisor shall report about the H2020 compliance of third country partners to the project. For ENVIRONMENT PROTECTION AND SAFETY (after GA, before the commencement of the research work): 1. If relevant, copies of facilities authorisations must be provided (security classification of laboratory). 2. The applicant must ensure that appropriate health and safety procedures conforming to relevant local/national guidelines/legislation are followed for staff involved in this project. For OTHER ETHICS ISSUES (throughout the project): 1. The Ethics coordinator must report to the REA with the periodic reports and the final report, and whenever it is considered to be necessary by the Ethics coordinator. 2. A complete portfolio of copies of all ethical approvals that cover all aspects of the research by all of the partners of the Consortium throughout the lifetime of the project must be compiled and retained by the Ethics Advisory and must be available to the REA if requested and for Ethics Checks or Audits.