Periodic Reporting for period 1 - EFHHBBBMS (Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory CentralNervous System lesion size and severity through Gas1 co-receptor modulation.)

In a healthy individual, the central nervous system (CNS) parenchyma is protected from the peripheral circulation by the blood–brain barrier (BBB). Importantly, during multiple sclerosis, the abnormal permeability of the BBB allows penetration into the CNS of inflammatory...