Periodic Reporting for period 1 - Bump-BET (Bump and Hole approach to elucidate function of individual bromodomains of BET proteins)

Small molecules can be used to probe the biological function of individual proteins, but achieving high selectivity against structurally similar paralogues remains a challenging task. The Bromo and Extra-Terminal (BET) proteins brd2, brd3, brd4 and brdt play important roles in...