Periodic Reporting for period 1 - LIGER (Identification of novel substrates for ubiquitin ligases involved in cell cycle and cell migration)

Protein degradation via the proteasome-ubiquitin system (UPS) plays a crucial role in cellular homeostasis. Defects in this system are often associated with pathologic states like cancer or developmental abnormalities. E3-ubiquitin ligases are responsible for substrate...