Periodic Reporting for period 1 - LEUKEYOLK (Uncovering the origin and mechanisms of Down syndrome-associated leukaemia through human induced pluripotent stem cell-derived haemopoiesis)

Childhood leukaemias manifest in the first few years of life, which suggests an embryonic origin of the diseases and a possible contribution of haemopoietic progenitor cells generated during embryonic life in driving these types of cancers. In this context, the Down...