Periodic Reporting for period 1 - CytoLysoReg (Cellular and Biophysical Approach to Understand the Cytokine-mediated Regulation of the Lysosomal Hydrolytic Capacity)

Dysfunction of lysosomes partakes the onset of multiple human pathologies. Even though the activity of lysosomal hydrolases was considered confined to the lysosomal lumen for more than 50 years, nowadays we know they localise in the nuclear and cytosolic compartment. These...