IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

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Authors: Silvia Gaggero , Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon , Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra

Journal title: Science Immunology

Journal publisher: American Association for the Advancement of Science

Published year: 2022

DOI identifier: 10.1126/sciimmunol.ade5686

ISSN: 2470-9468