Periodic Reporting for period 1 - Heart Fi-Re (HEART FIne REgulation through mechanosensing in myosin filaments: merging theory and experiments into a multi-scale heart simulator)

Muscle force is directly proportional to the number of myosin motors going through the so-called cross-bridge cycle, the ATP-driven interaction between myosin proteins, protruding from the thick filament, and actin proteins, forming the thin filament. Classically, the calcium...