Periodic Reporting for period 1 - ROCKSOFT (Rho GTPase cross-talk with syndecan-4 regulates pro-fibrotic mechanotransduction in the heart)

Cardiac fibrosis is a major cause of diastolic heart failure, and is induced by increased mechanical stress of the left ventricle. Treatment is currently lacking, reflecting a lack of understanding of cardiac fibroblast physiology, the main cell type responsible for...