Periodic Reporting for period 1 - RHOMBOSMALPS (Enabling malaria rhomboid proteases as drug targets: usage of molecular cookie cutters to shape novel activity assays and inhibitors.)

Intramembrane proteases (IMP) are proteolytic enzymes that are embedded in the lipid bilayer. Rhomboids a serine IMP subfamily which has been linked to important human diseases. For example, Plasmodium falciparum rhomboids 1 and 4, are thought to be key for the parasite...