Periodic Reporting for period 1 - Signalling-in-NODs (Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation)

Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, is a complex chronic inflammatory condition mainly affecting western societies. Although there has been progress in keeping inflammation down in chronic IBD, each therapy works only in a...