HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.

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Authors: Daniel B. Grabarczyk; Olga A Petrova; Luiza Deszcz; Robert Kurzbauer; Paul Murphy; Juraj Ahel; Antonia Vogel; Rebeca Gogova; Victoria Faas; Darja Kordic; Alexander Schleiffer; Anton Meinhart; Richard Imre; Anita Lehner; Jana Neuhold; Gerd Bader; Peggy Stolt-Bergner; Jark Böttcher; Bernhard Wolkerstorfer; Gerhard Fischer; Irina Grishkovskaya; David Haselbach; Dirk Kessler; Tim Clausen

Journal title: Nature Chemical Biology

Journal number: 8

Journal publisher: Nature Publishing Group

Published year: 2021

DOI identifier: 10.1038/s41589-021-00831-5

ISSN: 1552-4450