Periodic Reporting for period 1 - smSTRUCT (Fuse smFRET and modeling to a new structural biology method and solve the functional ESCRT assembly structure)

The project evolved towards a high-risk high-gain fundamental methods development project with the ultimate goal to understand how the ESCRT machinery works. We planned to combine powerful molecular modeling with single-molecule FRET (smFRET) experiments on individual ESCRT...