Periodic Reporting for period 1 - FLUOROKEF (Incorporation of unnatural fluorinated amino acids to probe the function of the bacterial efflux system Kef in a cellular setting.)

The ligand-gated bacterial potassium (K+) efflux system, Kef, is inhibited by glutathione (GSH) and activated by glutathione-S-conjugates (GS-X). Kef is evolutionarily conserved in many bacterial species and functions to protect bacteria against toxic electrophiles. Its vital...