Periodic Reporting for period 1 - skILL (Intracellular signalling by modified lipopolysaccharide)

Neisseria meningitidis typically produces a very potent hexa-acylated lipopolysaccharide (LPS) which is too toxic for therapeutic applications. An important determinant of this endotoxic activity is recognition of the membrane-anchoring lipid A moiety of LPS by the TLR4/MD-2...