Periodic Reporting for period 1 - SLIM (Synthetic Lethal Interactions with nucleophosMin 1)

Original aim of SLIM was to study the effect of NPM1 mutations on the sensitivity of acute myeloid leukaemia(AML) cells to commonly used drugs and tool compounds. Methodologically it was envisioned to use CRISPR/Cas9 based genome editing to generate matched cell line pairs...