Validation of new identified therapeutic agent or class of agents identified in WP4

Examine the potency of new compounds selected in WP4 using ex vivo reactivation studies on CD4 T cells reservoirs of HIV-1 infected patients on suppressive cART. Examine the cytotoxicity and T cell activation affect in primary PBMCs over periods of 24-72h, for new compounds to be tested in ex vivo latency assays.