Role of T cell metabolic pathways in the regulation of HIV latency/reactivation; Role of the SUMO pathway in the regulation of HIV latency/reactivation; Select drugs to be validated in WP5

Perform dose-response analysis and combinatorial studies for reactivation of HIV-1 gene expression using pharmacological compounds targeting T cell metabolic junction, and in vitro HIV-1 latency cellular models. Examine the role of SUMO effectors by lost-/gain-of-function studies using in vitro HIV-1 latency cellular models. Perform dose-response analysis and combinatorial studies for reactivation of HIV-1 gene expression using pharmacological compounds targeting selected SUMO pathway effectors using in vitro HIV latency models.