Periodic Reporting for period 1 - TaGFrag (Stabilising Protein-Protein Interactions: A Target-Guided Fragment-Based Approach)

The TaGFrag project aimed to discover novel, synthetically tractable small-molecule stabilisers of the therapeutically important 14-3-3σ – estrogen receptor alpha (ERα) protein-protein interaction (PPI). PPI stabilisation is an emerging strategy in drug discovery with the...