Periodic Reporting for period 1 - GERMINOID (Development of human primordial germ cells towards the onset of sperm and egg differentiation in a novel model culture system)

What is the problem/issue being addressed?The precise mechanisms regulating the origin and early development of human primordial germ cells (hPGCs) are not well understood, mainly because of technical reasons and the inaccessibility to early human post-implantation embryos...