Periodic Reporting for period 1 - Wnt and CRC (Therapeutic inhibition of the oncogenic Wnt/beta-catenin pathway in mismatch repair deficient hypermutant tumors)

Colorectal cancer (CRC) is a leading cause of death related to cancer with 1.6 million new cases per year worldwide and more than 800.000 deaths per year. Hypermutant CRC tumors affect 15-20% of all CRC patients and are characterized by presenting mutations in key components...