Scientific article of ESR13 on the tool for kinetic behaviour of crystallizing multicomponent chiral systems

This task will focus on enabling resolution through the crystallization behaviour. Chiral compounds can possess complex solid state, thermodynamic and crystallization behaviour. Pharmaceuticals have the tendency to form several competing solid forms, which may or may not enable chiral resolution. The crystallization of industrial chiral compounds takes place in complex multicomponent mixtures in which next to the enantiomers and solvent also other compounds (resolving agents, impurities, additives, anti-solvents) are influencing the process. Additionally, In hybrid reaction processes an additional complexity is the racemizing agent impacting on the phase diagram and crystallization behaviour. ESR13 will develop a screening tool quickly and reliably determine the crystallization-based resolution possibilities of a new chiral compound in multicomponent solutions.