Scientific article of ESR10 on methods to predict multicomponent conglomerate systems of chiral compounds

Only 5-10% of the chiral compounds form conglomerates while crystallization-based resolution techniques often rely on the discovery of a conglomerate forming system. This project will establish the formation principles of conglomerate co-crystals, salts, solvates and other solids using experimental screening as well as database mining and molecular simulation techniques. These formation principles will enable changing the solid state of a chiral compound from racemic compound to multicomponent conglomerate and thus open up the route towards resolution. This would lead to a 10-fold increase in the application of chiral resolution through preferential crystallization. ESR10 will develop crystal engineering approaches