Scientific article of ESR3 on Methods and Design Rules developed for Continuous Preferential Crystallization Techniques

This part will be led by MM at ETH with the involvement of ESR3 at OVGU and ESR4 at ETH. Both ESRs will have an approach that combines process modelling and experiments. Single enantiomeric crystals can be produced in different ways. If sufficient enrichment in the target enantiomer can be achieved by an upstream asymmetric synthesis step or by an ancillary technique, e.g. chiral chromatography, then a rather conventional cooling or antisolvent crystallization can be carried out. These processes exist both in the batch and in the continuous mode, which exhibit however different performance. Alternatively, there are at least two techniques, namely preferential crystallization and Viedma ripening, that allow forming single enantiomeric crystals starting from a racemic mixture (50/50 of the two enantiomers) using a very small amount of seeds of the target enantiomer. These processes have so far been operated in a batch mode, and making them continuous is a challenge. This task will deliver tools to design Crystallization-enabled Continuous Resolution Processes.