Scientific article of ESR12 on the tool to determine competing solid state behaviour in multicomponent chiral systems

This task will focus on enabling resolution through the crystallization behaviour. Chiral compounds can possess complex solid state, thermodynamic and crystallization behaviour. Pharmaceuticals have the tendency to form several competing solid forms, which may or may not enable chiral resolution. The crystallization of industrial chiral compounds takes place in complex multicomponent mixtures in which next to the enantiomers and solvent also other compounds (resolving agents, impurities, additives, anti-solvents) are influencing the process. Additionally, In hybrid reaction processes an additional complexity is the racemizing agent impacting on the phase diagram and crystallization behaviour. ESR12 will develop a screening tool for complex solid state and thermodynamic behaviour of chiral compounds in multicomponent solutions.