Late-occurring and long-circulating metabolites of GABA Aα2,3 receptor modulator AZD7325 involving metabolic cyclization and aromatization: relevance to MIST analysis and application for patient compliance

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Authors: Chungang Gu, Markus Artelsmair, Charles S Elmore, Richard J Lewis, Patty Davis, James E Hall, Bruce T Dembofsky, Greg Christoph, Mark A Smith, Marc Chapdelaine, Maria Sunzel

Journal title: Drug Metabolism and Disposition

Journal number: 46/3

Journal publisher: American Society for Pharmacology and Experimental Therapeutics

Published year: 2018

Published pages: dmd.117.078873

DOI identifier: 10.1124/dmd.117.078873

ISSN: 0090-9556