Comprehensive, quantitative mathematical description of PAR polarity

Developing a comprehensive, quantitative mathematical description of PAR polarity will involve a) Defining mobility parameters for PAR network components, including diffusion coefficients and membrane association/dissociation rates, b) Defining binding parameters governing pairwise interactions between PAR com-ponents. c) Construction and analysis of a model of PAR polarity based on parameters in (a) and (b) to identify core design principles of PAR network.