Contributive role of CNS barriers in achievement of extracellular and intracellular unbound compound exposure in brain regions of interest in rats in relation to seizure- inducing activity of the compounds

Defining contributing role of bloodbrainbarrier in achievement of extracellular and intracellular unbound compound exposure in brain regions of interest in rats in relation to the seizurogenic activity of the compounds Key neuropharmacokinetic parameters in rats will be reported for investigated compounds Unbound free extracellular and intracellular brain exposureresponse relationship will be presented with the focus on potential contributive role of CNS barriers on modulation of brain exposure during the course of the treatment with known seizurogenic compounds