Multiscale integrative modeling and novel AE biology

Report on discovery analytics platform COSS to model related to Mechanism of ActionMoAtoAdverse Event AE and drugtoAE knowledge and use this information eg knowledge on biomarkers pathways targets in order to feed and improve in vivo in vitro toxicity assessment tools and machine learning models and tools for using them for predictions The report will include all supporting evidence relevant literature data etc in a fitforpurpose format suitable for implementation as an algorithm SOP or invitrovivo assay characteristic Interim technical reports will present and structure all knowledge existing and novel gained from the in silico in vitro an in vivo tools in an attempt to construct elements of an AOP eg mechanistic interpretation of drug characteristics key initiating events molecular cellular and physiological etc and adverse outcomes pertinent to each of the three categories PNS CNS PP of interest to the project