Report on the proof-of-concept animal studies

Insert at least 3 devices to 3 groups of the models of D2.4 (5-6/group) via burred holes. Groups will receive additional implants as follows:(I) a reprogramming organoid; (II, positive control) iNSC expressing TRAIL (pro-apoptotic). (III, negative control), iNSCs without reprogramming miRNA. Daily measurements until regression or death: (i) distance between iR-NSCs and GBM; (ii) power and time required of RF for secretion, (iii) fluorescent signal at receiver. Histology will confirm if positive signal correlates with GBM recurrence.