D5.13 Selection of 3 compounds able to inhibit the NLRP3 inflammasome activation in the low micro/nanomolar range endowed with drug-like properties

The compounds identified in silico simulations will be synthesized and tested in vitro to verify the anti-inflammatory effect. Best performing compounds will be selected according to preliminary ADME experiments. At least one compound will be identified for further in vivo studies and patenting.