Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

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Authors: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira

Journal title: Journal of Medicinal Chemistry

Journal number: 00222623

Journal publisher: American Chemical Society

Published year: 2013

Published pages: 7679-7690

DOI identifier: 10.1021/jm4011466

ISSN: 0022-2623