Periodic Reporting for period 1 - KLKs4OvCa (Targeting human kallikreins involved in ovarian cancer pathogenesis: novel activity based probes and kallikrein-based therapeutic strategies.)

Aberrant protein ubiquitination and degradation are linked to the pathogenesis of several diseases including cancer, neurodegeneration, and metabolic diseases, that would benefit from targeted protein stabilization (TPS). Heterobifunctional molecules able to induce targeted...