Periodic Reporting for period 1 - StructuRNP (Cryo-EM structural analysis of small nuclear ribonucleoprotein particles (snRNP) biogenesis)

Pre-mRNA splicing is carried out by the dynamic and multi-megadalton spliceosome, which assembles anew on each intron from pre-formed small nuclear ribonucleoprotein particles (snRNPs; U1, U2, U4, U5, U6) and non-snRNP proteins. The U2-U6 snRNPs undergo major compositional and...