Periodic Reporting for period 1 - GLoopID (Mechanisms underlying regulation and removal of G-quadruplex/R-loop transcription-replication conflicts)

Guanine-rich repetitive DNA sequences, which can form four-stranded structures (G-quadruplex or G4), preferentially form in single stranded DNA (ssDNA) upon transient melting and can also occur in RNA. Transcribed G4s often co-exist with stable DNA:RNA hybrids forming a...