A cell-adapted SARS-CoV-2 mutant, showing a deletion in the spike protein spanning the furin cleavage site, has reduced virulence at the lung level in K18-hACE2 mice.

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Authors: Fabrizia Valleriani, Chiara Di Pancrazio, Massimo Spedicato, Giovanni Di Teodoro, Daniela Malatesta a b, Tetyana Petrova a b, Francesca Profeta, Maria Loredana Colaianni c, Shadia Berjaoui , Ilaria Puglia, Marialuigia Caporale, Emanuela Rossi, Maurilia Marcacci, Mirella Luciani, Flavio Sacchini, Ottavio Portanti, Francesco Bencivenga, Nicola Decaro, France

Journal title: Virology

Journal publisher: Virology

Published year: 2024

DOI identifier: 10.1016/j.virol.2024.109997

ISSN: 1096-0341