Periodic Reporting for period 1 - MACROVALVE (Understanding the role of macrophages in the structural degeneration of bioprosthetic heart valve leaflets)

The prevalence of aortic valve (AV) stenosis in those ≥75 years of age is 12.4% and the incidence increases with age. Accordingly, the number of patients requiring valve replacement yearly will rise to over 850,000 globally by 2050. Currently, the only treatment option for...