Novel 3-Sulfonamide Dual-Tail Pyrrol-2-one Bridged Molecules as Potent Human Carbonic Anhydrase Isoform Inhibitors: Design, Synthesis, Molecular Modeling Investigation, and Anticancer Activity in MeWo, SK-BR-3, and MG-63 Cell Lines

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Authors: Cristina M. Al-Matarneh, Natalia Simionescu, Alina Nicolescu, Mihaela Silion, Andrea Angeli, Niccolò Paoletti, Alessandro Bonardi, Paola Gratteri, Mariana Pinteala, Claudiu T. Supuran

Journal title: Journal of Medicinal Chemistry

Journal publisher: American Chemical Society (ACS)

Published year: 2025

DOI identifier: 10.1021/acs.jmedchem.4c02586

ISSN: 0022-2623