Demonstration of ToF-SIMS for surface characterization & bionanointeractions

Summary
The aim is to systematically evaluate and optimize sample preparation methods for chemical imaging such as timeofflight secondary ion mass spectrometry ToFSIMS in order to characterize NMs in complex matrices such as biological media under close to reallife conditions Therefore sample preparation will be optimized towards lowest possible alteration of the sample including NMs localization preservation of the chemical contentspeciation of the NMs as well as cellular or extracellular structures