Demonstration of CE for corona characterization

Standardised capillary electrophoresis methodologies for the characterisation of NMs using optical detection methods will be developed CESIMS connection of CE to Mass Spectrometry using ultra lowflow ESI will be used for the detailed characterisation of the coronal proteome and metabolome by CESIMS This latter approach is orthogonal to published work using LCMS and can be expected to offer advantages when working with charged and polar compounds as well as intact proteins Integration with LCMS is an interesting approach and will help validating the CESIMS approach