Obtaining review board approval

Regarding the use of human cell lines, all procedures involving patient samples will be approved by the local review board (Comité Ético de Investigación Clínica de La Rioja, CEICLAR) and will adhere to the tenets of the Declaration of Helsinki. Patients would have to sign an informed consent form. With regards to animal use, all the animal experimentation will follow the ethical policy consistent with the principles of “reduction, replacement, refinement, responsibility” (4R) and will be run under the current EU and national legislation on animal welfare. Specifically, Directive 2010/63/EU on the protection of animals used for scientific purposes and RD 53/2013 about the basic rules for the protection of animals used for experimental and other scientific purposes, including teaching.