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Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

Project: ANTIVIRALS

Updated at: 28-04-2024

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Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Pr...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Project acronym ANTIVIRALS

Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues

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Updated at: 28-04-2024

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Snapshots of ADP-ribose bound to Getah virus macro domain reveal an intriguing choreography

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Updated at: 28-04-2024

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Chikungunya virus nonstructural protein 1 as an antiviral target

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Updated at: 28-04-2024

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Recruitment

Project: ANTIVIRALS

Updated at: 28-04-2024

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ESR weblog

Project: ANTIVIRALS

Updated at: 28-04-2024

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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

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Updated at: 28-04-2024

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Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based a...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of t...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Meeting report: 31st International Conference on Antiviral Research

Project: ANTIVIRALS

Updated at: 28-04-2024

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Characterization of the Golgi c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replicatio...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

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Updated at: 28-04-2024

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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Project: ANTIVIRALS

Updated at: 28-04-2024

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Viral rewiring of cellular lipid metabolism to create membranous replication compartments

Project: ANTIVIRALS

Updated at: 28-04-2024

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No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells

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Updated at: 28-04-2024

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International conference

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Updated at: 28-04-2024

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Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Cond...

Project: ANTIVIRALS

Updated at: 28-04-2024

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A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA ...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

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Updated at: 28-04-2024

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Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites

Project: ANTIVIRALS

Updated at: 28-04-2024

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Bypassing pan-enterovirus host factor PLA2G16

Project: ANTIVIRALS

Updated at: 28-04-2024

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An orthogonal proteomic survey uncovers novel Zika virus host factors

Project: ANTIVIRALS

Updated at: 28-04-2024

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ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Pr...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals

Project: ANTIVIRALS

Updated at: 28-04-2024

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Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

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Updated at: 28-04-2024

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Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets ...

Project: ANTIVIRALS

Updated at: 28-04-2024

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Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

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Updated at: 28-04-2024

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Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidy...

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Updated at: 28-04-2024

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Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro

Project: ANTIVIRALS

Updated at: 28-04-2024

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Project acronym ANTIVIRALS

Resources

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Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Pr...

Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues

Snapshots of ADP-ribose bound to Getah virus macro domain reveal an intriguing choreography

Chikungunya virus nonstructural protein 1 as an antiviral target

Recruitment

ESR weblog

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based a...

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of t...

Meeting report: 31st International Conference on Antiviral Research

Characterization of the Golgi c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replicatio...

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Viral rewiring of cellular lipid metabolism to create membranous replication compartments

No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells

International conference

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Cond...

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA ...

Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites

Bypassing pan-enterovirus host factor PLA2G16

An orthogonal proteomic survey uncovers novel Zika virus host factors

ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Pr...

Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals

Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets ...

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidy...

Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro