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Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Phenotypic manifestation of α-synuclein strainsderived from Parkinson’s disease and multiplesystem atrophy in human d...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Final evaluation of Impact Key Performance Indicators

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfac...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like s...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

How is alpha‐synuclein cleared from the cell?

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Structure-based classification of tauopathies

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Structures of α-synuclein filaments from multiple system atrophy

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Symposium on critical pathways of propagation and their relevance to human disease

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils f...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Cryo-EM structures of tau filaments from Alzheimer’s disease

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Les protéinopathies infectieuses de Parkinson et d’Alzheimer

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slic...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Tau in the brain interstitial fluid is fragmented and seeding–competent

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

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