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Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Phenotypic manifestation of α-synuclein strainsderived from Parkinson’s disease and multiplesystem atrophy in human d...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

How is alpha‐synuclein cleared from the cell?

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfac...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils f...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like s...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Structures of α-synuclein filaments from multiple system atrophy

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Structure-based classification of tauopathies

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Symposium on critical pathways of propagation and their relevance to human disease

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Final evaluation of Impact Key Performance Indicators

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slic...

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Tau Filaments and the Development of Positron Emission Tomography Tracers

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ATPase and AMPA receptors

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Project: IMPRiND

Updated at: 29-04-2024

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Cryo-EM structures of tau filaments from Alzheimer’s disease

Project: IMPRiND

Updated at: 29-04-2024

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Project acronym IMPRiND

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Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in...

Phenotypic manifestation of α-synuclein strainsderived from Parkinson’s disease and multiplesystem atrophy in human d...

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

How is alpha‐synuclein cleared from the cell?

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfac...

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils f...

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like s...

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Structures of α-synuclein filaments from multiple system atrophy

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease...

Structure-based classification of tauopathies

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

Symposium on critical pathways of propagation and their relevance to human disease

Final evaluation of Impact Key Performance Indicators

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slic...

Tau Filaments and the Development of Positron Emission Tomography Tracers

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ATPase and AMPA receptors

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Cryo-EM structures of tau filaments from Alzheimer’s disease