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Identification of sequence changes in myosin II that adjust muscle contraction velocity

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

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Project: SILICOFCM

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Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Inhibitory potency of Valsartan/Sacubitril drug combination: molecular docking simulations

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Variational Gaussian Mixture Models with robust Dirichlet concentration priors for virtual population generation in hype...

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Semi-Automatic Left Ventricle Model Generation

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Updated at: 29-04-2024

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Imaging acquisition data

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Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar prope...

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

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Project: SILICOFCM

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Generation of virtual patients for in silico cardiomyopathies drug development

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Tuning Cooperativity of Calcium Activation in Cardiac Muscle

Project: SILICOFCM

Updated at: 29-04-2024

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Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Project: SILICOFCM

Updated at: 29-04-2024

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Road map on Business Model v2

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrat...

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Heart Mechanical Model Based on Holzapfel Experiments

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model

Project: SILICOFCM

Updated at: 29-04-2024

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FLUID-ELECTRO-MECHANICAL PARAMETRIC MODEL OF THE LEFT VENTRICLE

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Multi-scale striated muscle contraction model linking sarcomere length-dependent cross-bridge kinetics to macroscopic de...

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Generation of virtual patient data for in-silico cardiomyopathies drug development using tree ensembles: a comparative s...

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior

Project: SILICOFCM

Updated at: 29-04-2024

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Requirements Analysis

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Computational model for simulation of left ventricle behaviour during heart beat

Project: SILICOFCM

Updated at: 29-04-2024

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Prognostic Value of NT-Pro Brain Natriuretic Peptide During Exercise Recovery in Ischemic Heart Failure of Reduced, Midr...

Project: SILICOFCM

Updated at: 29-04-2024

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Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

Workflow for drug testing

Project: SILICOFCM

Updated at: 29-04-2024

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Project acronym SILICOFCM

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Identification of sequence changes in myosin II that adjust muscle contraction velocity

Project Website

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

Inhibitory potency of Valsartan/Sacubitril drug combination: molecular docking simulations

Variational Gaussian Mixture Models with robust Dirichlet concentration priors for virtual population generation in hype...

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Semi-Automatic Left Ventricle Model Generation

Imaging acquisition data

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar prope...

Project videos

Generation of virtual patients for in silico cardiomyopathies drug development

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Tuning Cooperativity of Calcium Activation in Cardiac Muscle

Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Road map on Business Model v2

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrat...

Heart Mechanical Model Based on Holzapfel Experiments

Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP

3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model

FLUID-ELECTRO-MECHANICAL PARAMETRIC MODEL OF THE LEFT VENTRICLE

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data

Multi-scale striated muscle contraction model linking sarcomere length-dependent cross-bridge kinetics to macroscopic de...

Generation of virtual patient data for in-silico cardiomyopathies drug development using tree ensembles: a comparative s...

Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior

Requirements Analysis

Computational model for simulation of left ventricle behaviour during heart beat

Prognostic Value of NT-Pro Brain Natriuretic Peptide During Exercise Recovery in Ischemic Heart Failure of Reduced, Midr...

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Workflow for drug testing