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GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Informing β-cell regeneration strategies using studies of heterogeneity

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Dimerization of the Sodium/Iodide Symporter

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independe...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distributio...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule b...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and ...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Periodic Reporting for period 4 - OptoBETA (Multicellular regulation of insulin secretion from pancreatic islets)

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Re...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Optical tools for understanding the complexity of β-cell signalling and insulin release

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 di...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dy...

Project: OptoBETA

Updated at: 27-04-2024

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Project acronym OptoBETA

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GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Informing β-cell regeneration strategies using studies of heterogeneity

Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons

Dimerization of the Sodium/Iodide Symporter

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independe...

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distributio...

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule b...

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and ...

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase...

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

Periodic Reporting for period 4 - OptoBETA (Multicellular regulation of insulin secretion from pancreatic islets)

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Re...

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Optical tools for understanding the complexity of β-cell signalling and insulin release

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 di...

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dy...