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Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated...

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic refe...

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

Inhibition of<i>CERS1</i>in skeletal muscle exacerbates age-related muscle dysfunction

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

A platform for experimental precision medicine: The extended BXD mouse family.

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strain...

Project: UPRmt

Updated at: 01-06-2024

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Project acronym UPRmt

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

The mouse metallomic landscape of aging and metabolism

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Plat...

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Genetic background and sex control the outcome of high-fat diet feeding in mice.

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Mitocellular communication: Shaping health and disease

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Niacin: an old lipid drug in a new NAD+ dress

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

NAD+ homeostasis in health and disease

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Mouse Systems Genetics as a Prelude to Precision Medicine

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Identifying gene function and module connections by the integration of multispecies expression compendia

Project: UPRmt

Updated at: 27-04-2024

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Periodic Reporting for period 2 - UPRmt (The Mitochondrial Unfolded Protein Response)

Project: UPRmt

Updated at: 27-04-2024

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Project acronym UPRmt

Resources

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Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated...

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic refe...

Inhibition of<i>CERS1</i>in skeletal muscle exacerbates age-related muscle dysfunction

A platform for experimental precision medicine: The extended BXD mouse family.

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strain...

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

The mouse metallomic landscape of aging and metabolism

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Plat...

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Genetic background and sex control the outcome of high-fat diet feeding in mice.

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Mitocellular communication: Shaping health and disease

Niacin: an old lipid drug in a new NAD+ dress

NAD+ homeostasis in health and disease

Mouse Systems Genetics as a Prelude to Precision Medicine

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Identifying gene function and module connections by the integration of multispecies expression compendia

Periodic Reporting for period 2 - UPRmt (The Mitochondrial Unfolded Protein Response)