Periodic Reporting for period 2 - evolSingleCellGRN (Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks)

One of the most profound insights from the genomics era is that most variation among individuals is due not to mutations affecting coding genes but rather mutations affecting how, when, and where genes are expressed. These non-coding mutations are also disproportionately...