Periodic Reporting for period 4 - HybReader (Mechanisms of epigenetic gene regulation by R-loops)

R-loops, three-stranded DNA-RNA hybrids, are formed by invasion of an RNA strand into duplex DNA and can be assembled either co-transcriptionally (cis R-loops) or by local unwinding of DNA and subsequent hybridization of homologous RNA fragments (trans R-loops). R-loops have...